According to our computer projections, the Louisville Cardinals will beat the Indiana Hoosiers when the two teams match up at Lucas Oil Stadium on Saturday, September 16, which begins at 12:00 PM. For our predictions on the spead, point total, and final score, see the rest of the article below.

Looking to bet on Louisville vs. Indiana? Head to BetMGM using our link to claim a first-time depositor bonus!

Indiana vs. Louisville Predictions and Picks

ATS Pick Total Pick Score Prediction
Indiana (+10) Toss Up (50.5) Louisville 28, Indiana 21

Sportsbook Promo Codes

Sign up at BetMGM using our link.

Week 3 Big Ten Predictions

Indiana Betting Info (2023)

  • The implied probability of a win by the Hoosiers based on the moneyline is 25.6%.
  • The Hoosiers is 1-0-0 against the spread this year.
  • In games it has played as at least 10-point underdogs this season, Indiana is 1-0 against the spread.
  • No Hoosiers one games with a set total this season have hit the over.
  • The average point total for Indiana this year is 9.0 points higher than this game's over/under.

Watch live sports and more on Fubo! Click here to sign up for a free trial.

Louisville Betting Info (2023)

  • Based on this game's moneyline, the Cardinals' implied win probability is 78.9%.
  • The Cardinals have one win against the spread this season.
  • Louisville has a perfect 1-0 ATS record when playing as at least 10-point favorites.
  • One of the Cardinals' two games this season has gone over the point total.
  • The point total average for Louisville games this season is 53.0, 2.5 points higher than the over/under for this matchup.

Rep your team with officially licensed college football gear! Head to Fanatics to find jerseys, shirts, and much more.

Hoosiers vs. Cardinals 2023 Scoring Insights

Pts Pts Allowed Home Pts Home Pts Allowed Away Pts Away Pts Allowed
Louisville 47.5 17.0 56.0 0.0 -- --
Indiana 22.0 15.0 22.0 15.0 -- --

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.