In Vanderburgh County, the I-69/164 northbound ramp to State Road 57 southbound at Exit 18 is closing for up to three weeks.
There will be signs to detour traffic to loop back through the cloverleaf exit at I-64 and approach the exit from I-69/164 southbound.
Crews are repairing bridge joints and applying a thin overlay.
In Owensboro, Rachel Place from Ottawa Drive to Lydia Drive has been closed since Tuesday for street repair.
Drivers should use caution while traveling in the area, and a detour is posted.
The road is expected to reopen sometime Friday.
In Gibson County, the sheriff's office says the stoplight at U.S. 41 & State Road 68 is flashing red and should be treated as a four way stop.