Secretary of State John Kerry sat down with Israeli Prime Minister Benjamin Netanyahu Tuesday in Jerusalem.
Kerry is in the region to jump start stalled peace talks with the Palestinians.
Speaking to reporters Tuesday morning he said that the differences between Palestinians and Israelis could be overcome.
Netanyahu told Kerry that he was ready to sit down and talk.
"I am determined to not only to resume the peace process with the Palestinians but to make a serious effort to end this conflict once and for all. This has economic components we welcome any initiative that you or any others will bring forward in this regard. But it also has a political component; political discussions that will address a myriad of issues foremost on our minds are the question of recognition and security. This is a real effort," said Netanyahu.
Kerry also commented on Iran's controversial nuclear program.
"Iran cannot have and will not have a nuclear weapon," said Kerry. "The United States of America has made clear that we stand not just with Israel but with the entire international community in making it clear that we are serious, we are open to negotiation, but it is not an open-ended endless negotiation. It cannot be used as an excuse for other efforts to try to break out with respect to a nuclear weapon."
This is the second visit to the Middle East for Kerry this year.