The polls are already open in the eastern time zone, and the nation is watching the outcome of a race involving a local candidate.
State Treasurer Richard Mourdock of Vanderburgh County is the Republican candidate for U.S. Senator.
He's taking on Democrat Joe Donnelly.
Richard Mourdock is expected to vote at the Vanderburgh County 4-H Center at 6 a.m.
The Vanderburgh County native who ousted long-time Senator Richard Lugar in the May Primary, spent his final day campaigning across the state Monday.
Most of the day he appeared alongside Senator Dan Coats.
His opponent, Joe Donnelly, also took advantage of those final hours - crossing the state with former Senator Evan Bayh.
Andrew Horning, a Libertarian, is also running.
A recent poll shows Donnelly with a double-digit lead over Mourdock.
Mourdock dismissed polling that shows Donnelly taking a lead in the race following Mourdock's comment that a pregnancy resulting from rape is "something God intended."
That poll showed Donnelly taking a sizable lead among women voters after the comment.
Meanwhile, Joe Donnelly was set to vote in South Bend, Indiana Tuesday morning.
Voting centers are open 6 a.m.-6 p.m. Tuesday.
You can vote at any of the 23 vote centers.
Stay up to date on wait lines on the Vanderburgh County App.
Stay with 14 News for the most up-to-date results and election coverage.