Colts interim coach Bruce Arians says rookie tight end Coby Fleener and cornerback Vontae Davis will not play Sunday against Miami.
Both were injured last weekend at Tennessee.
Davis left less than three minutes into the game with a left knee injury. Fleener left just before halftime after hurting his left shoulder.
Arians says he hopes both starters will return to Indy's lineup in a couple of weeks.
Fleener was a second-round draft pick and one of Andrew Luck's college teammates at Stanford before coming to Indy. He is third on the team with 21 receptions.